The CREATE Seminar

December 4, 2015  Orlando, FL

A Bridge For Transdisciplinary Research

Hematology and Genetic Engineering working for a cure.

A Bridge For Transdisciplinary Research

Myeloproliferative Neoplasms

william-dameshek-tufts-university

“It is possible that these various conditions –”myeloproliferative disorders’”  — are all somewhat variable manifestations of proliferative activity of the bone marrow cells, perhaps due to a hitherto undiscovered stimulus. This may affect the marrow cells differently or irregularly with the result that various syndromes, either clear-cut or transitional, result. —William Dameshek  “Some Speculations on the Myeloproliferative Syndromes” Blood, 1951

Arising among hematopoietic stem and progenitor cells in the marrow deep in the blood-bone niche…  Read More

The CREATE Seminar

The CREATE (CRISPR/Cas enhanced autologous transplant exploration) Seminar is a multidisciplinary on-going process to evaluate the potential use of gene-edited cells in myelofibrosis and other hematologic stem cell transplantation settings.
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Organized by the MPN Research Foundation and MPN Genetics Network, the first meeting of CREATE is a satellite luncheon December 4, 2015 before the opening of the American Society of Hematology annual meeting in Orlando.  The CREATE seminar brings together scientists and medical professionals to explore the possibilities of developing autologous transplantation for myelofibrosis and other MPN patients:

Featured Speakers:

rachel-cas92-cropped-e1441669364678Rachel Haurwitz. PhD is a co-founder of Caribou Biosciences and has been president and CEO since its inception. She has extensive research experience in the field of CRISPR biology and has contributed both to the discovery of components of the CRISPR immune system and to the invention of new technologies based on CRISPR-associated proteins. In 2014, she was named by Forbes Magazine to the “30 Under 30” list in Science and  Read More…

CRISPR/Cas9

PCR_tubes wiki

CRISPR/Cas9 – Several billion years in the making

It’s more than a little ironic that the hottest new biotech tool for gene editing should have been invented several billion years ago, just about the time the Earth cooled down enough to start being fruitful and multiplying.

Micro-organisms struggling to survive evolved a vaccination system that is the template for today’s CRISPR technology for editing genes. Repeated DNA sequences, called CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) are genetic elements..

Read More…

Making History — CRISPR and JAK2

JAK2 genomic location

Zhaohui had a problem. A very little problem.

He was hunting for a small target.  It was a single gene, a few micronanometers of DNA, that had mutated and was blighting an MPN patient’s life. The gene was located somewhere on a six foot long DNA strand, nestled among 3 billion look-alike base pairs glittering on a double helix skeleton of sugar and phosphate… Read More

 

Foundation Funds CRISPR Research

Bob Behind Desk

Blood Cancer Foundations offer $200,000 CRISPR research grants.

The MPN Research Foundation, with its partner, the Leukemia and Lymphoma Society, will award two-year grants of $100,000 per year for research into Gene Editing as Applied to MPNs.

Read More…